Prostaglandin E1 infusions for vascular insufficiency in progressive systemic sclerosis.
نویسندگان
چکیده
منابع مشابه
Prostaglandin E1 infusions for vascular insufficiency in progressive systemic sclerosis.
Twelve patients with systemic sclerosis (SS) and severe Raynaud's phenomenon received infusions of prostaglandin E1 (PGE1) at a dose of 6-10 ng/kg/min, with either saline or 5% dextrose, for 72 hours in a single-blind cross-over study. The infusions were administered intravenously by centrally positioned catheters. Infusions were well tolerated with only mild side effects. Following the PGE1 in...
متن کاملEffects of prostaglandin E1 on microvascular haemodynamics in progressive systemic sclerosis.
The effects of prostaglandin E1 infusion on nailfold capillary haemodynamics were studied in eight patients with Raynaud's phenomenon secondary to progressive systemic sclerosis. Using a modified Landis microinjection technique the mean (+/- SEM) transcapillary pressure gradient was increased during and six weeks after infusion by 13.9 +/- 3.2 cm H2O (p less than 0.05) and 5.5 +/- 2.5 cm H2O (p...
متن کاملProgressive systemic sclerosis.
The pulmonary manifestations of progressive systemic sclerosis (PSS) are important determinants of a patient’s prognosis. Although the etiology and pathogenesis of PSS are unknown, it is recognized that this is a complex disease; it is likely that different genetic susceptibilities and environmental exposures lead to the disease in different individuals. Individuals with diffuse PSS tend to dev...
متن کاملCyclic adenine nucleotide levels in lymphocytes from patients with systemic sclerosis: efficiency of prostaglandin infusions.
Basal intracellular cAMP levels of lymphocytes from patients with systemic sclerosis, all suffering from Raynaud's phenomenon, were significantly lower than those obtained from normal controls. Moreover, the cAMP response to isoprenaline of these patients' lymphocytes was inhibited. Intravenous infusion of prostaglandins (E1 and I2) restored the basal levels and greatly improved the responsiven...
متن کاملradiological findings in progressive systemic sclerosis (p.s.s.)
radiological findings of 20 patients with scleroderma have been described. we had cornmon and uncommon roentgen signs of scleroderma similar to other series and one case with mid esophagus narrowing which we think have not been reported previously.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1981
ISSN: 0003-4967
DOI: 10.1136/ard.40.4.350